CREGS00040 (MIR-273 Version 2)

From CREGS

Sequence Logo (What is a sequence logo ?)

IUPAC Consensus Sequence (What is the IUPAC code ?)

CAATCTGTTGTATGGGTAC[1]

Regulatory element length

19 base pairs

Status

Tested in vitro

Predicted by miRBase

Description & Comments

miRNA binding site in 3'UTR of die-1 downregulates die-1 transcripts

Similarity to other CREGS motifs

Similarity to motifs in other organisms

Motif bound by

MIR-273 [1]:Also known to bind:

CREGS00039_(MIR-273 Version 1)

CREGS00040_(MIR-273 Version 2)

Expression Pattern

• Expressed
• Tissues & cells:
  • neurons
  • ASER

References

1. Chang S, Johnston RJ Jr, Frøkjaer-Jensen C, Lockery S, and Hobert O. MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode. Nature 2004 Aug 12; 430(7001) 785-9. doi:10.1038/nature02752 pmid:15306811. PubMed HubMed [KEY-15306811]

All Medline abstracts: PubMed HubMed

Motif Representation Formats

Information Content Matrix (Total IC 38 )

A [  0.00 2.00 2.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 2.00 0.00 0.00 0.00 0.00 0.00 2.00 0.00 ]
C [  2.00 0.00 0.00 0.00 2.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 2.00 ]
G [  0.00 0.00 0.00 0.00 0.00 0.00 2.00 0.00 0.00 2.00 0.00 0.00 0.00 2.00 2.00 2.00 0.00 0.00 0.00 ]
T [  0.00 0.00 0.00 2.00 0.00 2.00 0.00 2.00 2.00 0.00 2.00 0.00 2.00 0.00 0.00 0.00 2.00 0.00 0.00 ]

Position Frequency Matrix

A [    0  12  12   0   0   0   0   0   0   0   0  12   0   0   0   0   0  12   0 ]
C [   12   0   0   0  12   0   0   0   0   0   0   0   0   0   0   0   0   0  12 ]
G [    0   0   0   0   0   0  12   0   0  12   0   0   0  12  12  12   0   0   0 ]
T [    0   0   0  12   0  12   0  12  12   0  12   0  12   0   0   0  12   0   0 ]

Position Weight Matrix

A [  -2.16  1.73  1.73 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16  1.73 -2.16 -2.16 -2.16 -2.16 -2.16  1.73 -2.16 ]
C [   1.73 -2.16 -2.16 -2.16  1.73 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16 -2.16  1.73 ]
G [  -2.16 -2.16 -2.16 -2.16 -2.16 -2.16  1.73 -2.16 -2.16  1.73 -2.16 -2.16 -2.16  1.73  1.73  1.73 -2.16 -2.16 -2.16 ]
T [  -2.16 -2.16 -2.16  1.73 -2.16  1.73 -2.16  1.73  1.73 -2.16  1.73 -2.16  1.73 -2.16 -2.16 -2.16  1.73 -2.16 -2.16 ]