CREGS00032 (MEC-3 Version 1)

From CREGS

Sequence Logo (What is a sequence logo ?)

IUPAC Consensus Sequence (What is the IUPAC code ?)

ATAATNNAT[1][2][3]

Regulatory element length

9 base pairs

Status

Tested both in vivo & in vitro

Predicted by Experiment

Description & Comments

Though able to bind on it own Mec-3 forms a heterodimer with UNC-86 in vivo which increases its affinity to the bs

Similarity to other CREGS motifs

CREGS00029_(UNC-86 Version 1) (0.819 Rev. Comp. ) CREGS00031_(UNC-86 & MYSTERY TF Version 1) (0.903) [[| (0.000)]]

Similarity to motifs in other organisms

Motif bound by

MEC-3 [2][1][3]

Expression Pattern

• Expressed
• Tissues & cells:
  • Neuorns

References

1. Xue D, Finney M, Ruvkun G, and Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J 1992 Dec; 11(13) 4969-79. pmid:1361171. PubMed HubMed [KEY-1361171]
2. Xue D, Tu Y, and Chalfie M. Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science 1993 Sep 3; 261(5126) 1324-8. pmid:8103239. PubMed HubMed [KEY-8103239]
3. Lichtsteiner S and Tjian R. Synergistic activation of transcription by UNC-86 and MEC-3 in Caenorhabditis elegans embryo extracts. EMBO J 1995 Aug 15; 14(16) 3937-45. pmid:7664734. PubMed HubMed [KEY-7664734]

All Medline abstracts: PubMed HubMed

Motif Representation Formats

Information Content Matrix (Total IC 14 )

A [  2.00 0.00 2.00 2.00 0.00 0.00 0.00 2.00 0.00 ]
C [  0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 ]
G [  0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 ]
T [  0.00 2.00 0.00 0.00 2.00 0.00 0.00 0.00 2.00 ]

Position Frequency Matrix

A [   12   0  12  12   0   3   3  12   0 ]
C [    0   0   0   0   0   3   3   0   0 ]
G [    0   0   0   0   0   3   3   0   0 ]
T [    0  12   0   0  12   3   3   0  12 ]

Position Weight Matrix

A [   1.73 -2.16  1.73  1.73 -2.16  0.00  0.00  1.73 -2.16 ]
C [  -2.16 -2.16 -2.16 -2.16 -2.16  0.00  0.00 -2.16 -2.16 ]
G [  -2.16 -2.16 -2.16 -2.16 -2.16  0.00  0.00 -2.16 -2.16 ]
T [  -2.16  1.73 -2.16 -2.16  1.73  0.00  0.00 -2.16  1.73 ]