Welcome to our web page for mapping the genetic basis of traits.
Our mapping method can quickly and precisely find the genomic locations of adaptive mutations associated with experimentally and
naturally evolved quantitative traits. The method is based on linkage analysis applied to a single pool of segregants that express the trait of interest,
also known as Bulk Segregant Analysis, and the genotyping is done using high-density oligonucleotide microarrays. The method was tested in budding yeast,
Saccharomyces cerevisiae on five known genes that were mapped to a resolution of 0.2-24 kb (0.1-10 cM),
and could be extended to other organisms.
For comments or questions please contact:
Laboratory of Andrew Murray
Molecular and Cellular Biology Department, Harvard University
16 Divinity Avenue, Cambridge, MA 02138, USA
asegre [at] broad [dot] mit [dot] edu
Tel: 617-496-1489 - Fax: 617-496-1541
[Saccharomyces Genome Database]
© Copyright, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138
Last updated August 6, 2006